Formaldehyde → N-allyl-2-methoxy-3-morpholino-2-(2-pyridyl)thiopropanamide

HRID 1604889Notes

Reaction equation

[CH2:1]([NH:4][C:5](=[S:15])[CH:6]([O:13][CH3:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH:2]=[CH2:3].[CH2:16]=O.[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>>[CH2:1]([NH:4][C:5](=[S:15])[C:6]([O:13][CH3:14])([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH2:16][N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)[CH:2]=[CH2:3]

Participants

Reactant 3

HCID 712Formaldehyde

HCID 8083Morpholine

HCID 15581963N-allyl-2-methoxy-2-(2-pyridyl)thioacetamide

Product 1

HCID 53972982N-allyl-2-methoxy-3-morpholino-2-(2-pyridyl)thiopropanamide

Procedure

Reacting N-allyl-2-methoxy-2-(2-pyridyl)thioacetamide with formaldehyde and morpholine by the procedure of Example 1 gives N-allyl-2-methoxy-3-morpholino-2-(2-pyridyl)thiopropanamide.

Sources & evidence

ORD record: ord-96258939ed934b89821f1e872130bc2b
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03948892

Reaction notes

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