Formaldehyde → HCID 53996258, compound

HRID 1604895Notes

Reaction equation

HRID 1604895 reaction equation
[CH3:1][N:2]([CH3:14])[CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[C:4]([NH:6][CH3:7])=[S:5].[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.[CH2:21]=O>CO>[CH3:14][N:2]([CH3:1])[C:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)([CH2:21][N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)[C:4]([NH:6][CH3:7])=[S:5]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8083MorpholineHCID 15581954HCID 15581954, compound

Product 1

HCID 53996258HCID 53996258, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 19.5 g. of 2-dimethylamino-N-methyl-2-(2-pyridyl)thioacetamide in 200 ml. of methanol, 13 g. of morpholine and 4.5 g. of formaldehyde is heated at reflux for 48 hours. The mixture is concentrated in vacuo and the residue is recrystallized from isopropyl ether to give 2-dimethylamino-N-methyl-3-morpholino-2-(2-pyridyl)thiopropanamide.

Workup

  1. additionA mixture of 19.5 g
  2. temperatureat reflux for 48 hours
  3. concentrationThe mixture is concentrated in vacuo
  4. customthe residue is recrystallized from isopropyl ether

Sources & evidence

ORD record
ord-f6931484944846fbbf93bff2c14fb04f
Source dataset
uspto-grants-1976_04
Patent number
US03948892

Reaction notes

Loading…