Thionyl Chloride → o-Bromomethylphenylacetyl chloride

HRID 1604911Notes

Reaction equation

HRID 1604911 reaction equation
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=O.S(Cl)([Cl:15])=O>>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([Cl:15])=[O:12]

Participants

3

Reactant 2

HCID 24386Thionyl Chloride2×HCID 12889260[2-(Bromomethyl)phenyl]acetic acid

Product 1

HCID 12211419o-Bromomethylphenylacetyl chloride

Procedure

A solution of 0.18 g of o-bromomethylphenylacetic acid in excess thionyl chloride is stirred at room temperature for 18 hours after which the unreacted thionyl chloride is removed under high vacuum to give o-bromomethylphenylacetyl chloride as an oily residue.

Workup

  1. customis removed under high vacuum

Sources & evidence

ORD record
ord-73b5b3f5a77c42619385d190248ae8a3
Source dataset
uspto-grants-1976_04
Patent number
US03948904

Reaction notes

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