HCID 131710132, compound → HCID 131710131, compound

Participants

Reaction Steps

Diphenylmethyl 3-methoxymethyl-7β-(2'-thienylacetamido)-ceph-3-em-4-carboxylate (2 g.,) was dissolved in a mixture of trifluoroacetic acid (8 ml) and anisole (2 ml) and after 5 minutes the reagents removed under reduced pressure. The resulting gum was dissolved in ethyl acetate and poured into 60°-80° petroleum and the product recovered by filtration. This material crystallised from ethyl acetate as colourless prisms, m.p. 153°-157° (decomp.), [α]D25 + 81.6°(c 1, tetrahydrofuran), λmax (ethanol) 237, 260 (Sh.) nm (ε 13,700 and 7,700 respectively), νmax (Nujol) 1780 (β-latham), 1720 (-COOH), 1690 and 1524 cm-1 (-CONH), N.M.R. 5,80 (-CH2OCH3), 6.70τ (-CH2OCH3), (Found: C, 49.2; H, 4.4; N, 7.5; S, 17.0. C15H16N2O5S2 requires: C, 48.9; H, 4.4; N, 7.6; S, 17.4%).

Provenance & Evidence