Isopropylamine → 2,4,6-Tri-isopropylamino-5-nitro-pyrimidine

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Reaction Steps

1.15 g (0.005 mol) of 2,4,6-trichloro-5-nitropyrimidine are dissolved in 50 ml of alcohol and the solution is then treated with 2.9 g (0.05 mol) of isopropylamine. The mixture is stirred for 3 hours at room temperature after the temperature has first risen to 35°C, and then it is evaporated. The residue is treated with 100 ml of water and extracted twice with ether. The ethereal extract is dried over MgSO4 for 4 hours, filtered, and evaporated, to yield 1.1 g of 2,4,6-tri-isopropylamino-5-nitro- pyrimidine as an oil; b.p. 185°C at 0.001 Torr.

Provenance & Evidence