Ethyl 4-bromo-3-oxobutanoate → Ethyl 2-hydroxy-4-methyl-1,3-thiazole-5-carboxylate

Participants

Reaction Steps

84 g of ethyl thiocarbamate were added to 500 ml of dioxane and then 168 g of ethyl α-bromoacetylacetate was added thereto dropwise. The mixture was refluxed for 4 hours and the solvent was then evaporated under reduced pressure. The solid residue was crystallized from benzene to obtain 72g of 5-ethoxycarbonyl-4-methyl-4-thiazoline-2-one in the form of white crystals melting at 172°C.

Provenance & Evidence