Dichloromethane → HCID 12464891, compound

Participants

Reaction Steps

3.5 G of phenylisocyanate are added dropwise to a stirred solution of 7.78 g of 3-[2-(4-aminopiperazin-1-yl) ethyl]-5,6-dimethoxy-2-methylindole in 100 ml. of dry methylene chloride while maintaining the reaction temperature below 35° C. After 2 hours, 50 ml. of ether are added, the product is filtered and washed with ether. The product is recrystallized from ethyl acetate to give a white solid, m.p. 170°-173°C. of 1-[1-(5,6 -dimethoxy-2-methylindol-3-ylethyl)piperazin-4-yl]-3-phenylurea.

Provenance & Evidence