反应详情

By following essentially the same procedure but starting with (a) 3-[2-(4-aminopiperazin-1-yl)ethyl]-2-methylindole and 3,5-dimethoxyphenylisocyanate; (b) 3-[2 -(4-aminopiperazin-1-yl)ethyl]-2-ethylindole and butylisocyanate; and (c) 3-[2-(4-aminopiperazin-1-yl)ethyl]-5,6-dimethoxyindole and 3,4,5-trimethoxyphenylisocyanate, it is possible to obtain (a) 1-[1-(2-methylindol-3-ylethyl)piperazin-4-yl]-3-(3,5-dimethoxyphenyl)urea; (b) 1-[1-(2-ethylindol-3-ylethyl)piperazin-4-yl]-3-butylurea; and (c) 1-[1-(5,6-dimethoxyindol-3-ylethyl)piperazin-4-yl]-3-(3,4,5-trimethoxyphenyl)urea, respectively.