Acetic Anhydride → HCID 12251780, compound

HRID 1605019Notes

Reaction equation

HRID 1605019 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][N:12]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]([O:22][CH3:23])=[O:21])[CH:10]=2)=[CH:5][CH:4]=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>N1C=CC=CC=1>[C:24]([N:13]1[C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[CH:10][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([O:22][CH3:23])=[O:21])=[N:12]1)(=[O:26])[CH3:25]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178497612HCID 178497612, compound

Product 1

HCID 12251780HCID 12251780, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 5.0 g of 5-(4-methoxyphenyl)-3-(2-carbomethoxyphenyl)pyrazole, 3.5 g of acetic anhydride, and 25 ml of pyridine was allowed to stir overnight at 25°. The mixture was poured into 100 ml of ice water, and the product was extracted with benzene. Recrystallization from hexane-ethyl acetate (2:1) gave 1-acetyl-3-(2-carbomethoxyphenyl)-5-(4-methoxyphenyl)pyrazole, mp 119°-121°.

Workup

  1. extractionthe product was extracted with benzene
  2. customRecrystallization from hexane-ethyl acetate (2:1)

Sources & evidence

ORD record
ord-c627323c52954e5890db693e56fe4ff4
Source dataset
uspto-grants-1976_04
Patent number
US03948937

Reaction notes

Loading…