Sodium Carbonate → HCID 21418513, compound

HRID 1605066Notes

Reaction equation

HRID 1605066 reaction equation
[C:1]([C:4]1[CH:40]=[CH:39][C:7]([O:8][CH2:9][CH:10]([OH:38])[CH2:11][O:12][C:13]2[CH:34]=[CH:33][C:16]3[C:17](=[O:32])[CH:18]=[C:19]([C:21]4[CH:31]=[CH:30][C:24]([C:25]([O:27]CC)=[O:26])=[CH:23][CH:22]=4)[O:20][C:15]=3[C:14]=2[CH2:35][CH2:36][CH3:37])=[C:6]([CH2:41][CH2:42][CH3:43])[C:5]=1[OH:44])(=[O:3])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:1]([C:4]1[CH:40]=[CH:39][C:7]([O:8][CH2:9][CH:10]([OH:38])[CH2:11][O:12][C:13]2[CH:34]=[CH:33][C:16]3[C:17](=[O:32])[CH:18]=[C:19]([C:21]4[CH:31]=[CH:30][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=4)[O:20][C:15]=3[C:14]=2[CH2:35][CH2:36][CH3:37])=[C:6]([CH2:41][CH2:42][CH3:43])[C:5]=1[OH:44])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 21549030HCID 21549030, compound

Product 1

HCID 21418513HCID 21418513, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This ester was hydrolysed by heating under reflux with 30 mls of 10% sodium carbonate solution and 30 mls of ethanol for one hour. The solution was acidified to give a solid which was crystallised from ethanol three times to give 1.4g of 4-(7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy] -4-oxo-8-propyl-4H-1-benzopyran-2-yl)benzoic acid, melting point, 204°-206°C.

Workup

  1. temperatureby heating
  2. customto give a solid which
  3. customwas crystallised from ethanol three times

Sources & evidence

ORD record
ord-f1e607b7ad974e04a52af10603e1850a
Source dataset
uspto-grants-1976_04
Patent number
US03948955

Reaction notes

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