反应详情

A mixture of 10 g. of 1,1-dimethoxy-7-chloro-3,7-dimethyloctane, one equivalent of thiourea and 100 ml. of 95% ethanol is refluxed for about 24 hours. Then a solution of 1.5 equivalents of sodium hydroxide in 50 ml. of water is added and the mixture refluxed for about 2 hours. After cooling to about room temperature, the solution is carefully acidified and ether is added. The organic layer is separated, washed with water, dried over calcium sulfate and evaporated to give 1,1-dimethoxy-7-mercapto-3,7-dimethyloctane which is purified by distillation.

1. additionA mixture of 10 g
2. temperaturethe mixture refluxed for about 2 hours
3. temperatureAfter cooling to about room temperature
4. customThe organic layer is separated
5. washwashed with water
6. dry with materialdried over calcium sulfate
7. customevaporated