Chloroacetaldehyde → 1,4,5,6-Tetrahydropyrimidine-1-acetaldehyde

HRID 1605154Notes

Reaction equation

HRID 1605154 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][N:3]=[CH:2]1.Cl[CH2:8][CH:9]=[O:10]>CC(C)=O>[N:3]1([CH2:8][CH:9]=[O:10])[CH2:4][CH2:5][CH2:6][N:1]=[CH:2]1

Participants

4

Reactant 2

HCID 33ChloroacetaldehydeHCID 1371051,4,5,6-Tetrahydropyrimidine

Product 1

HCID 540906671,4,5,6-Tetrahydropyrimidine-1-acetaldehyde

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 8.4 g. of 1,4,5,6-tetrahydropyrimidine and 7.8 g. of chloroacetaldehyde is refluxed in 100 ml. of acetone for two hours. The solvent is removed in vacuo and the residue is taken up in water and neutralized with 1N sodium hydroxide. Extracting with chloroform, drying and removing the solvent in vacuo gives 1,4,5,6-tetrahydropyrimidine-1-acetaldehyde.

Workup

  1. additionA mixture of 8.4 g
  2. customThe solvent is removed in vacuo
  3. extractionExtracting with chloroform
  4. customdrying
  5. customremoving the solvent in vacuo

Sources & evidence

ORD record
ord-deeaae5d34c84c6b9cf15fd60d23cb72
Source dataset
uspto-grants-1976_04
Patent number
US03949076

Reaction notes

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