反应详情

A mixture of 8.4 g. of 1,4,5,6-tetrahydropyrimidine and 7.8 g. of chloroacetaldehyde is refluxed in 100 ml. of acetone for two hours. The solvent is removed in vacuo and the residue is taken up in water and neutralized with 1N sodium hydroxide. Extracting with chloroform, drying and removing the solvent in vacuo gives 1,4,5,6-tetrahydropyrimidine-1-acetaldehyde.

1. additionA mixture of 8.4 g
2. customThe solvent is removed in vacuo
3. extractionExtracting with chloroform
4. customdrying
5. customremoving the solvent in vacuo