HCID 53859967, compound → HCID 21500130, compound

Participants

Reaction Steps

The mixture of 5.0 g of 7-fluoro-1-methyl-2,3,4,5-tetrahydro-1-benzazepine-2,5-dione-4-carboxylic acid methyl ester, 2.3 g of 4-fluoroaaniline and 120 ml of xylene is refluxed under nitrogen for 40 hours, cooled with ice and diluted with 65 ml of petroleum ether. The precipitate formed is filtered off and recrystallized from acetonitrile, to yield the 7-fluoro-1-methyl-4-(4-fluorophenylcarbamoyl)-2,3,4,5-tetrahydro-1-benzazepine-2,5-dione melting at 180°-182°.

Provenance & Evidence