Ethyl 2-Formylpropionate → 4-Methyl-1-(3,4-dichlorobenzyl)-pyrazol-5-one

HRID 1605165노트

반응식

HRID 1605165 반응식
C(O[C:4](=[O:9])[CH:5]([CH:7]=O)[CH3:6])C.[Cl:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:14][NH:15][NH2:16]>C(O)C>[CH3:6][C:5]1[C:4](=[O:9])[N:15]([CH2:14][C:13]2[CH:17]=[CH:18][C:19]([Cl:20])=[C:11]([Cl:10])[CH:12]=2)[NH:16][CH:7]=1

참가 물질

4

반응물 2

HCID 10898741Ethyl 2-FormylpropionateHCID 20495842HCID 20495842, 화합물

생성물 1

HCID 233344004-Methyl-1-(3,4-dichlorobenzyl)-pyrazol-5-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 7.5 g of α-formylpropionic acid ethyl ester in 50 ml ethanol were added dropwise 10.9 g 3,4-dichlorobenzylhydrazine. After stirring overnight at room temperature, the solvent was distilled off in a vacuum and the solid residue was recrystallized from ethanol. m.p. 156°C, 9.3 g (64% of theory).

후처리

  1. distillationthe solvent was distilled off in a vacuum
  2. customthe solid residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-68ce431cca5e431d8f9b711471992dc0
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03949083

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