HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyphenol → 1,3-Dimethyl-4-(m-methoxyphenyloxy)-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyphenol | HCID 9007 | — |
| Reactant | Tetramethylurea | HCID 12437 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Benzene, 1-bromo-2,4-dimethyl- | HCID 68503 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1,3-Dimethyl-4-(m-methoxyphenyloxy)-benzene | HCID 21549657 | — |
Reaction Steps
A mixture of 1,3-dimethyl-4-bromobenzene, 10.5 g. of m-methoxyphenol, 4.65 g. of cuprous oxide, 40 ml. of tetramethylurea, and 75 ml. of N-methylpyrrolidone is stirred at 165° for 96 hours. The resultant mixture is diluted with water and extracted with methylene chloride. The methylene chloride extracts are chromatographed on 300 g. of alumina with gradient elution using hexane:ether to give 1,3-dimethyl-4-(m-methoxyphenyloxy)-benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03949084 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-6b639ce2671f4045b8a7ddbf95e838ee |
| Source note | uspto-grants-1976_04 |