Pyridine → 1-Methylcyclobutyl Chloroformate

Participants

Reaction Steps

A solution of 0.55 gm. (6.5 mM) of 1-methylcyclobutanol, and 0.44 ml. of pyridine in 10 ml. of benzene is added to a solution of phosgene in 10 ml. of benzene at 0°C. over a 30 minute period. The reaction is allowed to stir for 30 minutes and then filtered to remove pyridine hydrochloride formed during the reaction. Excess phosgene is removed by evaporation at reduced pressure and the volume of the benzene solution is reduced to 4-5 ml; the benzene solution of 1-methylcyclobutylchloroformate is employed in the following reaction.

Provenance & Evidence