Dichloromethane → N-(1-methylcyclobutyloxycarbonyl) phenylalanine alanine methyl ester

Participants

Reaction Steps

A solution of 0.67 mM of the hydroxysuccinimide ester of N-(1-methylcyclobutyloxycarbonyl) phenylalanine and 0.70 mM of alanine methyl ester hydrochloride in 10 ml. of methylene chloride is treated with triethylamine until the pH is adjusted to 7.6-8.0. Reaction is stirred 6 hours and the reaction mixture is washed according to the following procedure: one time with dilute sodium bicarbonate solution; once with 50% saturated sodium chloride solution; once with 0.2 N sulfuric acid saturated with sodium sulfate; and two times with 50% saturated sodium chloride solution. The resulting material is dried over sodium sulfate and the washing procedure repeated. The solvent is removed in vacuo to afford N-(1-methylcyclobutyloxycarbonyl) phenylalanine-alanine methyl ester.

Provenance & Evidence