HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1605192Generated: October 31, 2026
Dicyclohexylcarbodiimide → N-(1-Methylcyclobutyloxycarbonyl)-Aspartic Anhydride
https://huagongshe.com/reaction/1605192
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-(1-methylcyclobutyloxycarbonyl) aspartic acid | HCID 54120717 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(1-Methylcyclobutyloxycarbonyl)-Aspartic Anhydride | HCID 54330780 | — |
Reaction Steps
A solution of 2.45 g. of N-(1-methylcyclobutyloxycarbonyl)-aspartic acid in 50 ml. of dioxane is prepared and 2.2 g. of dicyclohexylcarbodiimide is added with vigorous stirring. After stirring at 25°C. for 2 hours, the dicyclohexylurea is removed by filtration and the dioxane removed by evaporation in vacuo. The resulting solid is substantially pure N-(1-methylcyclobutyloxycarbonyl)-aspartic anhydride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03948971 |
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| Source dataset | uspto-grants-1976_04 |
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| ORD ID | ord-8d14d03cac0a414181a57490d0193c1f |
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| Source note | uspto-grants-1976_04 |
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