反应详情

A stirred mixture of 5.97 g. (0.03 mole) of (4-chloro-6-methyl-2-pyrimidinylthio)acetonitrile, 4.2 g. (0.03 mole) of 4-chlorobenzylamine and 3.15 g. (0.03 mole) of sodium carbonate in 150 ml of absolute ethanol was heated under reflux for 6 hours. The mixture was filtered and the filtrate evaporated in a rotary evaporator. The residue was triturated with petroleum ether containing a little ethanol. The solid which crystallized was collected and recrystallized from ethyl acetate with petroleum ether added to induce precipitation affording 3.2 g. of product, m.p. 99°-101°.

1. additionA stirred mixture of 5.97 g
2. temperatureunder reflux for 6 hours
3. filtrationThe mixture was filtered
4. customthe filtrate evaporated in a rotary evaporator
5. customThe residue was triturated with petroleum ether containing a little ethanol
6. customThe solid which crystallized
7. customwas collected
8. customrecrystallized from ethyl acetate with petroleum ether
9. additionadded
10. customprecipitation
11. customaffording 3.2 g