反应详情

A stirred mixture of 15.0 g. (0.075 mole) of (4-chloro-6methyl-2-pyrimidinylthio)aceto nitrile, 10.0g. (0.075 mole) p-anisidine and 7.5 g. (0.075 mole) of sodium carbonate in 150 ml of ethanol was heated under reflux for five hours. The mixture was filtered and the filtrate was evaporated in a rotary evaporator. The oily residue was dissolved in ethyl acetate. Dilution of the ethyl acetate solution with petroleum ether and cooling in ice yielded a precipitate. This solid was collected and recrystallized from a mixture of benzene-petroleum ether to afford 7.2 g. of product, m.p. 128°-131°.

1. additionA stirred mixture of 15.0 g
2. temperatureunder reflux for five hours
3. filtrationThe mixture was filtered
4. customthe filtrate was evaporated in a rotary evaporator
5. dissolutionThe oily residue was dissolved in ethyl acetate
6. temperatureDilution of the ethyl acetate solution with petroleum ether and cooling in ice
7. customyielded a precipitate
8. customThis solid was collected
9. customrecrystallized from a mixture of benzene-petroleum ether
10. customto afford 7.2 g