Sodium Carbonate → HCID 54392575, compound

Participants

Reaction Steps

A mixture of 6.60 g. (0.02 mole) of [4-(p-chlorobenzylamino)-6-propyl-2-pyrimidinylthio]acetonitrile, 2.76 g. (0.04 mole) of hydroxylamine hydrochloride and 8.48 g. (0.08 mole) of sodium carbonate in 100 ml of N,N-dimethylformamide was heated on a steam bath for three and one-half hours. The mixture was filtered, diluted with 250 ml of water and extracted with 100 ml of ether. The ether layer was dried over magnesium sulfate, filtered and evaporated in a rotary evaporator. The residue was dissolved in ethanol, diluted with petroleum ether and cooled in ice. The precipitate which formed was collected and recrystallized from a mixture of ethanol-petroleum ether to give the analytical sample, m.p. 50° dec.

Provenance & Evidence