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Piperazine, 1-propyl-, hydrochloride (1:2) → 2-(4'-Propylpiperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine, 1-propyl-, hydrochloride (1:2) | HCID 415812 | — |
| 反応物 | 2-Chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydropyrido(2,3-d)pyrimidine | HCID 12266805 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-(4'-Propylpiperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine | HCID 22756840 | 84.6% |
反応手順
As described in Example XII, the condensation of 2.8 g of 2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine with 2.2 g of 1-propyl-piperazine, in chloroform (40 cm3) gives, after the treatments described in Example XII. 3.14 g of 2-(4'-propyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido-(2,3-d)pyrimidine (yield 84%); melting point 149°C, after recrystallisation from ethyl acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03950338 |
| 出典データセット | uspto-grants-1976_04 |
| ORD ID | ord-e522e7dbf95145efb8fc64d8dbffee5d |
| 出典メモ | uspto-grants-1976_04 |