反应详情

2-(4'-Allyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine is prepared, in a yield of 79%, by condensing 2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine with 1-allyl-piperazine, as indicated in the preceding Examples. It is a solid which melts in two stages; melting point 131°C, solidification, followed by melting point 143°C [after recrystallization from a mixture of benzene (1 volume) and isopropyl ether (1 volume)].

1. customafter recrystallization
2. additionfrom a mixture of benzene (1 volume) and isopropyl ether (1 volume)]