N-Nitro-S-methylisothiourea → HCID 178433317, compound

Participants

Reaction Steps

A solution of 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole (1.7 g.) and S-methyl-N-nitroisothiourea (1.45 g.) in methanol (35 ml.) was heated at 50°-60° for 2.5 hours and then set aside at room temperature for 48 hours. The crystalline product was filtered off and recrystallised from methanol to give N-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N'-nitroguanidine, m.p. 184°186°. (Found: C, 37.5; H, 5.7: N, 32.5; S, 12.5. C8H14N6O2S requires: C, 37.2; H, 5.5; N, 32.5; S, 12.4). (iii) Similarly reaction of N,S-dimethyl-N'-nitroisothiourea (1.6 g.) (m.p. 146°-147°, formed by the treatment of N,S-dimethylisothiouronium methosulphate with fuming nitric acid and concentrated sulphuric acid at -20°) with 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole by the above procedure followed by chromatographic purification on a column of silica gel with acetone as eluant, gives N-methyl-N'-[2-((4-methyl- 5-imidazolyl)methylthio)ethyl]-N"-nitroguanidine (1.23 g.), m.p. 112°-114°. (Found: C, 39.5; H, 6.2; N, 30.6; S, 11.5. C9H16N6O2S requires: C, 39.7; H, 5.9; N, 30.9; S, 11.8).

Provenance & Evidence