Ethylenediamine → HCID 178484973, compound

HRID 1605322Notes

Reaction equation

HRID 1605322 reaction equation
ClC[C:3]1[N:8]=[CH:7]C=[CH:5][N:4]=1.C(N)C[NH2:11].[N:13]1[CH:18]=[CH:17][CH:16]=[N:15][C:14]=1[CH2:19][NH:20][CH2:21][CH2:22][NH2:23].CN=C=S>>[C:5]([NH:4][C:3]([NH:8][CH3:7])=[N:23][CH2:22][CH2:21][NH:20][CH2:19][C:14]1[N:15]=[CH:16][CH:17]=[CH:18][N:13]=1)#[N:11]

Participants

5

Reactant 4

HCID 3301EthylenediamineHCID 11167Methyl isothiocyanateHCID 128773712-(Chloromethyl)pyrimidineHCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Product 1

HCID 178484973HCID 178484973, compound

Procedure

Reaction of 2-chloromethylpyrimidine with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(2-pyrimidylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) gives, after concentrating and chromatographing, N-methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea. This thiourea is reacted with lead cyanamide by the procedure of Example 3(b) to give the title compound.

Workup

  1. customgives
  2. concentrationafter concentrating
  3. customThis thiourea is reacted with lead cyanamide by the procedure of Example 3(b)

Sources & evidence

ORD record
ord-6d3f5eca409a48ad9e657ccf14bfe6ab
Source dataset
uspto-grants-1976_04
Patent number
US03950333

Reaction notes

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