Water → HCID 68132120, compound

Participants

Reaction Steps

To a solution of 0.494 g (1.0 mmole) of 2,2,2-trichloroethyl 3-fluoromethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide in 5 ml CH3CN and 2 ml DMF at 0° is added 0.207 g (1.1 mmole) anhydrous SnCl2 and 0.40 g (5 mmole) acetyl chloride and the resulting mixture is stirred at 0° for 1.0 hrs, then at 25° for 1.0 hour, and then poured into water and extracted with ethyl acetate. The ethyl acetate layer is washed with 3% HCl solution, 5% NaHCO3 solution, and water, and then dried (MgSO4) and stripped in vacuo to give 2,2,2-trichloroethyl 3-fluoromethyl-7-phenylacetamido-3-cephem-4-carboxylate, which can be purified by chromatography on silica gel with chloroform.

Provenance & Evidence