HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Pyridazineethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 20557795 | HCID 20557795 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Pyridazineethanol | HCID 14691468 | — |
Reaction Steps
3-Pyridazineacetic acid is esterified with anhydrous ethanolic hydrogen chloride and the resulting ethyl ester is reduced with lithium aluminium hydride in tetrahydrofuran to give 3-(2-hydroxyethyl)pyridazine. Treating this hydroxyethyl compound with thionyl chloride gives 3-(2-chloroethyl)pyridazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03950353 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-d4e730bce4374117a4a67686d9ca0ed5 |
| Source note | uspto-grants-1976_04 |