HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanediamine → N-(3-aminopropyl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanediamine | HCID 428 | — |
| Reactant | 2-Bromopyrimidine | HCID 78345 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(3-aminopropyl)pyrimidin-2-amine | HCID 14397405 | — |
Reaction Steps
Reaction of 2-bromopyrimidine with 1,3-diaminopropane in ethanol containing sodium ethoxide gives 2-(3-aminopropylamino)pyrimidine which on reaction with methyl isothiocyanate results in the production of N-methyl-N'-[3-(2-pyrimidylamino)propyl]thiourea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03950353 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-73e44db5da7a45cebfd78dc4b82bec9a |
| Source note | uspto-grants-1976_04 |