Methyl Isocyanate → N-Methyl-N'-[2-(2-pyrazinylmethylamino)ethyl]urea

HRID 1605447Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 13910894N-(pyrazinylmethyl)ethylenediamine

Product 1

HCID 20557893N-Methyl-N'-[2-(2-pyrazinylmethylamino)ethyl]urea

Procedure

Reacting N-(2-pyrazinylmethyl)ethylenediamine with methyl isocyanate by the procedure of Example 24, then concentrating and separating the residue by column chromatography gives the title compound.

Workup

concentrationconcentrating
customseparating the residue by column chromatography

Sources & evidence

ORD record: ord-9bf1ef6dce3c437e9051b6797071336c
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03950353

Reaction notes

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