Ethylenediamine → HCID 21546751, compound

HRID 1605477Notes

Reaction equation

HRID 1605477 reaction equation
[S:1]1[CH:5]=[CH:4][C:3](CNCCN)=[N:2]1.[CH2:11]([NH2:14])[CH2:12][NH2:13].BrCC1C=CSN=1.[CH3:22][N:23]=[C:24]=[O:25]>>[CH3:22][NH:23][C:24]([NH:13][CH2:12][CH2:11][NH:14][C:3]1[CH:4]=[CH:5][S:1][N:2]=1)=[O:25]

Participants

5

Reactant 4

HCID 3301EthylenediamineHCID 12228Methyl IsocyanateHCID 130375983-(bromomethyl)IsothiazoleHCID 20557777N-(3-isothiazolylmethyl)ethylenediamine

Product 1

HCID 21546751HCID 21546751, compound

Procedure

N-(3-Isothiazolylmethyl)ethylenediamine, prepared by reacting ethylenediamine with 3-bromomethylisothiazole by the procedure of Example 40(a), is reacted with methyl isocyanate by the procedure of Example 24 to give, after concentrating and separating by column chromatography, the title compound.

Workup

  1. customto give
  2. concentrationafter concentrating
  3. customseparating by column chromatography

Sources & evidence

ORD record
ord-39b75e07a0e9469b9c5c9650fbee7e43
Source dataset
uspto-grants-1976_04
Patent number
US03950353

Reaction notes

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