(2-Isothiocyanatoethyl)dimethylamine → N-(2-dimethylaminoethyl)-N'-[2-(3-isothiazolylmethylamino)ethyl]thiourea

HRID 1605478Notes

Reaction equation

HRID 1605478 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][NH:7][CH2:8][CH2:9][NH2:10])=[N:2]1.[CH3:11][N:12]([CH3:18])[CH2:13][CH2:14][N:15]=[C:16]=[S:17]>>[CH3:11][N:12]([CH3:18])[CH2:13][CH2:14][NH:15][C:16]([NH:10][CH2:9][CH2:8][NH:7][CH2:6][C:3]1[CH:4]=[CH:5][S:1][N:2]=1)=[S:17]

Participants

3

Reactant 2

HCID 3853726(2-Isothiocyanatoethyl)dimethylamineHCID 20557777N-(3-isothiazolylmethyl)ethylenediamine

Product 1

HCID 20557944N-(2-dimethylaminoethyl)-N'-[2-(3-isothiazolylmethylamino)ethyl]thiourea

Procedure

By the procedure of Example 40(a)(ii), N-(3-isothiazolylmethyl)ethylenediamine is reacted with 2-dimethylaminoethyl isothiocyanate to give N-(2-dimethylaminoethyl)-N' -[2-(3-isothiazolylmethylamino)ethyl]thiourea. Reacting with hydrobromic acid gives the hydrobromide salt.

Sources & evidence

ORD record
ord-99c3aff884b742e1ac58e4430f0d1700
Source dataset
uspto-grants-1976_04
Patent number
US03950353

Reaction notes

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