Hydroxyamine hydrochloride → HCID 178449945, compound

Participants

Reaction Steps

A mixture of 10 g of crystalline antibiotic X-537A and 5 g of hydroxylamine hydrochloride in 50 ml ethanol containing 5 ml pyridine was heated under reflux for 60 hours. The solution was evaporated to dryness and 5 ml water added. The solid product was triturated and filtered, then recrystallized from aqueous ethanol to give (-)-3-methyl-6-(7-ethyl-4-hydroxy-6-hydroxyimino-3,5-dimethyl-7-[5-ethyl-3-methyl-5-(5-ethyl-5-hydroxy-6-methyl-2-tetrahydro-pyranyl)-2-tetrahydrofuryl]heptyl) salicylic acid, hydroxylammonium salt; m.p. 168°-170°, [α]D25 -12.34° (1%, DMSO).

Provenance & Evidence