2-Iodobutane → 5-Amino-3-sec-butylthio-4-phenoxybenzoic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-amino-3-mercapto-4-phenoxybenzoic acid (2.6 g), sodium hydrogen carbonate (2 g), saturated sodium hydrogen carbonate (100 ml), and sec.-butyl iodide (2.2 g) is stirred for 6 hours at 55° C. After cooling, 5-amino-3-sec.-butylthio-4-phenoxybenzoic acid is precipitated by addition of hydrochloric acid until pH 2.5. After collection, recrystallization from aqueous ethanol, and drying in vacuo at 80° C, the compound is obtained with a melting point of 157°-159° C.

Provenance & Evidence