Oxygen → Glyphosate

Participants

Reaction Steps

A mixture of 10 g. of N-(phosphonomethyl) iminodiacetic acid, 170 mls. of water and 0.6 g. of commercial 5% palladium on carbon catalyst was placed in a pressure vessel and oxygen admitted to a pressure of 30 pounds per square inch. The mixture was continuously shaken at this pressure for 3 hours while maintaining the temperature at 90°-100°C. After cooling to room temperature, excess oxygen was vented, the catalyst removed by filtration and the filtrate concentrated to dryness at reduced pressure. The yield of 97% pure N-phosphonomethyl glycine was 7.3 g. (96% yield).

Provenance & Evidence