Hydrochloric Acid → HCID 178479228, compound

Participants

Reaction Steps

In order to carry out the reaction advantageously on an industrial scale, trans-4-cyanocyclohexane-1-carboxylic acid is hydrogenated at a room temperature under pressure in a hydrous methanol made alkaline by the addition of ammonia water in the presence of Raney nickel, and then the catalyst is filtered and the solvent is removed by distillation. When lower alkyl trans-4-cyanocyclohexane-1-carboxylate is used as a starting material, it is subjected to the same reaction and treatment as above, and the residue is hydrolyzed with dilute hydrochloric acid in a hot water bath to produce trans-4-aminomethyl-cyclohexane-1-carboxylic acid hydrochloride. The reaction solution is passed through a column of a weakly basic ion-exchange resin to obtain trans-4-aminomethylcyclohexane-1-carboxylic acid in an yield of from 85 to 95 percent.

Provenance & Evidence