反应详情

To a stirred solution of 3-benzylamino-5-nitro-4-phenylbenzoic acid (3.0 g) in a mixture of pyridine (15 ml) and water (15 ml), sodium dithionite (6.0 g) is added in portions during about 15 minutes. The mixture is heated on a steam bath for about 30 minutes, and is then evaporated in vacuo. The residue is treated with cold 1 N acetic acid (about 50 ml) and after cooling, the resulting precipitate is collected by filtration, washed with water and dried. After recrystallization twice from aqueous ethanol, 5-amino-3-benzylamino-4-phenylbenzoic acid is obtained with a melting point of 179°-181° C.

1. additionis added in portions during about 15 minutes
2. temperatureThe mixture is heated on a steam bath for about 30 minutes
3. customis then evaporated in vacuo
4. additionThe residue is treated with cold 1 N acetic acid (about 50 ml)
5. temperatureafter cooling
6. filtrationthe resulting precipitate is collected by filtration
7. washwashed with water
8. customdried
9. customAfter recrystallization twice from aqueous ethanol