反应详情

A mixture of 3-hydroxy-5-nitro-4-phenylbenzoic acid (22 g; prepared as in Example 2, step B), conc. sulfuric acid (10 ml) and ethanol (400 ml) is refluxed for 20 hours. The resulting solution is concentrated in vacuo to about 100 ml and is then diluted with water (about 300 ml). The separated ethyl 3-hydroxy-5-nitro-4-phenylbenzoate is collected by filtration, washed with water and dried. After recrystallization from carbon tetrachloride, the ester is obtained with a melting point of 128°-130° C.

1. temperatureis refluxed for 20 hours
2. concentrationThe resulting solution is concentrated in vacuo to about 100 ml
3. additionis then diluted with water (about 300 ml)
4. filtrationThe separated ethyl 3-hydroxy-5-nitro-4-phenylbenzoate is collected by filtration
5. washwashed with water
6. customdried
7. customAfter recrystallization from carbon tetrachloride