3-Ethoxy-5-nitro-4-phenylbenzoic acid → 5-Amino-3-ethoxy-4-phenylbenzoic acid

HRID 1605552Notes

Reaction equation

HRID 1605552 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([N+:24]([O-])=O)[C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]([OH:14])=[O:13])[C:2]1C=CC=CC=1.C(OC1C=C(C=C([N+]([O-])=O)C=1C1C=CC=CC=1)C(O)=O)C>>[NH2:24][C:16]1[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:9]([O:8][CH2:1][CH3:2])[CH:10]=[C:11]([CH:15]=1)[C:12]([OH:14])=[O:13]

Participants

3

Reactant 2

HCID 215468243-Ethoxy-5-nitro-4-phenylbenzoic acidHCID 215468443-Benzyloxy-5-nitro-4-phenylbenzoic acid

Product 1

HCID 215468185-Amino-3-ethoxy-4-phenylbenzoic acid

Procedure

By replacing in Example 2, step D, 3-benzyloxy-5-nitro-4-phenylbenzoic acid with 3-ethoxy-5-nitro-4-phenylbenzoic acid, and following the procedure described, 5-amino-3-ethoxy-4-phenylbenzoic acid is obtained with a melting point of 137.5°-138.5° C.

Sources & evidence

ORD record
ord-7657abe017fa45c2be4f4e5ed59b7c9c
Source dataset
uspto-grants-1976_04
Patent number
US03950380

Reaction notes

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