3-Benzylthio-5-nitro-4-phenylbenzoic acid → 5-Amino-3-benzylthio-4-phenylbenzoic acid

HRID 1605562Notes

Reaction equation

HRID 1605562 reaction equation
C(OC1C=C(C=C([N+]([O-])=O)C=1C1C=CC=CC=1)C(O)=O)C1C=CC=CC=1.[CH2:27]([S:34][C:35]1[CH:36]=[C:37]([CH:41]=[C:42]([N+:50]([O-])=O)[C:43]=1[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)[C:38]([OH:40])=[O:39])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[NH2:50][C:42]1[C:43]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)=[C:35]([S:34][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:36]=[C:37]([CH:41]=1)[C:38]([OH:40])=[O:39]

Participants

3

Reactant 2

HCID 215468223-Benzylthio-5-nitro-4-phenylbenzoic acidHCID 215468443-Benzyloxy-5-nitro-4-phenylbenzoic acid

Product 1

HCID 124087805-Amino-3-benzylthio-4-phenylbenzoic acid

Procedure

By replacing in Example 2, step D, 3-benzyloxy-5-nitro-4-phenylbenzoic acid with 3-benzylthio-5-nitro-4-phenylbenzoic acid, and following the procedure described, 5-amino-3-benzylthio-4-phenylbenzoic acid is obtained with a melting point of 173°-174° C.

Sources & evidence

ORD record
ord-4e04356288cc45a09731876c809f5f4e
Source dataset
uspto-grants-1976_04
Patent number
US03950380

Reaction notes

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