反应详情

A solution of 3-amino-4-phenyl-5-sulfamylbenzoic acid (1.46 g), 4-vinylpyridine (1.0 ml) and acetic acid (0.5 ml) in methanol (7.5 ml) is refluxed for 5-6 hours. After cooling, the resulting solution is diluted with water (16 ml) to precipitate crude 4-phenyl-3-(4-pyridylethylamino)-5-sulfamylbenzoic acid, which is collected by filtration, washed with water and dried. After recrystallization twice from aqueous ethanol, the acid is obtained with a melting point of 216.5°-217.5° C.

1. temperatureAfter cooling
2. customto precipitate crude 4-phenyl-3-(4-pyridylethylamino)-5-sulfamylbenzoic acid, which
3. filtrationis collected by filtration
4. washwashed with water
5. customdried
6. customAfter recrystallization twice from aqueous ethanol
7. customthe acid is obtained with a melting point of 216.5°-217.5° C.