Dimethylamine → 2-Amino-N,N-dimethyl-5-methoxy-benzylamine

HRID 1605596Notes

Reaction equation

HRID 1605596 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH2:4]O.S(Cl)(Cl)=O.[CH3:16][NH:17][CH3:18]>C(Cl)Cl>[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH2:4][N:17]([CH3:18])[CH3:16]

Participants

5

Reactant 3

HCID 674DimethylamineHCID 24386Thionyl ChlorideHCID 13756678(2-Amino-5-methoxyphenyl)methanol

Product 1

HCID 203190282-Amino-N,N-dimethyl-5-methoxy-benzylamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Amino-N,N-dimethyl-5-methoxy-benzylamine was prepared from 2-amino-5-methoxy-benzyl alcohol, thionyl chloride and dimethylamine analogous to Example 1. Proof of structure by IR-, UV- and NMR-spectra. IR-spectrum (methylenechloride):

Sources & evidence

ORD record
ord-e19c0be910bd4bf2a6d892bae45f1e82
Source dataset
uspto-grants-1976_04
Patent number
US03950393

Reaction notes

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