HCID 21547118, compound → HCID 21547111, compound

Participants

Reaction Steps

24.5 Gm (0.101 mol) of (E)-4-(2'-fluoro-4-biphenylyl)-3-butene-2-ol, dissolved in 300 ml of ethyl acetate, were hydrogenated at room temperature at a hydrogen pressure of 3 atmospheres in the presence of 8.5 gm of Raney-nickel until hydrogen absorption was complete. The catalyst was filtered off, the filtrate was evaporated in vacuo, and the residue was recrystallized twice from cyclohexane/petroleum ether (ratio by volume: 1:1). Yield: 15.0 gm (61% of theory) of colorless crystals, m.p. 59°-60°C.

Provenance & Evidence