Ethylamine → N-(1,3-dioxolan-2-yl)methyl ethylamine

A 40% by weight aqueous solution of ethylamine (100 ml) and 2-chloromethyl-1,3-dioxolane (35 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer. The reaction mixture is stirred for a period of about 18 hours. After this time sodium hydroxide (18 grams) is added with stirring over a period of about 4 hours. Stirring is then continued for an additional period of about 16 hours. The organic phase of the reaction mixture is then separated, washed with aqueous potassium carbonate and dried over anhydrous magnesium sulfate. The dried product is then distilled under reduced pressure to yield the desired product N-(1,3-dioxolan-2-ylmethyl)-N-ethylamine.

1. customequipped with a mechanical stirrer
2. stirringwith stirring over a period of about 4 hours
3. stirringStirring
4. waitis then continued for an additional period of about 16 hours
5. customThe organic phase of the reaction mixture is then separated
6. washwashed with aqueous potassium carbonate
7. dry with materialdried over anhydrous magnesium sulfate
8. distillationThe dried product is then distilled under reduced pressure

ORD record

ord-32b2814d3542456ba49442ecf059e816

Source dataset

uspto-grants-1976_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US03951640