Phosgene → HCID 21545032, compound

HRID 1605801Notes

Reaction equation

HRID 1605801 reaction equation
[CH3:1][S:2][C:3]1[S:4][C:5]([NH:8][CH3:9])=[N:6][N:7]=1.[C:10]([Cl:13])(Cl)=[O:11]>C1C=CC=CC=1>[CH3:1][S:2][C:3]1[S:4][C:5]([N:8]([CH3:9])[C:10]([Cl:13])=[O:11])=[N:6][N:7]=1

Participants

4

Reactant 2

HCID 6371Phosgene2×HCID 13650750HCID 13650750, compound

Product 1

HCID 21545032HCID 21545032, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

2-Methylthio-5-methylamino-1,3,4-thiadiazole (0.1 mole) and a solution of phosgene (0.11 mole) in benzene (200 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 4 hours. After this time the reaction mixture is stripped of benzene and unreacted phosgene to yield the desired product N-(2-methylthio-1,3,4-thiadiazol-5-yl)-N-methylcarbamoyl chloride.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux for a period of about 4 hours

Sources & evidence

ORD record
ord-22bf1aa08f3145ba8cd6d545bd653b06
Source dataset
uspto-grants-1976_04
Patent number
US03951640

Reaction notes

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