Phosgene → HCID 21544998, compound

HRID 1605803Notes

Reaction equation

HRID 1605803 reaction equation
[CH3:1][S:2]([C:5]1[S:6][C:7]([NH:10][CH3:11])=[N:8][N:9]=1)(=[O:4])=[O:3].[C:12]([Cl:15])(Cl)=[O:13]>C1C=CC=CC=1>[CH3:1][S:2]([C:5]1[S:6][C:7]([N:10]([CH3:11])[C:12]([Cl:15])=[O:13])=[N:8][N:9]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 6371Phosgene2×HCID 21544989HCID 21544989, compound

Product 1

HCID 21544998HCID 21544998, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

2-methylsulfonyl-5-methylamino-1,3,4-thiadiazole (0.1 mole) and a solution of phosgene (0.11 mole) in benzene (200 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 4 hours. After this time the mixture is stripped of benzene and unreacted phosgene to yield the desired product N-(2-methylsulfonyl-1,3,4-thiadiazol-5-yl)-N-methylcarbamoyl chloride.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux for a period of about 4 hours

Sources & evidence

ORD record
ord-35e84a15f8d549c9b0505dfb61038f27
Source dataset
uspto-grants-1976_04
Patent number
US03951640

Reaction notes

Loading…