2-Methylpropanimidamide hydrochloride → HCID 178503293, compound

Participants

Reaction Steps

A mixture of 19 g (0.15 mole) of isobutyramidine hydrochloride, 35 ml of methanol, 8.1 g (0.15 mole) of sodium methylate and 27 g (0.15 mole) of 2-methylmercaptoacetoacetic acid ethyl ester was stirred for 4 hours at 60°-70°C. The solvent was then distilled off under reduced pressure, the residue was dissolved in warm water and the solution was neutralized with acetic acid. The product which had crystallized out was filtered off. 13 g (44% of theory) of 2-isopropyl-4-hydroxy-5-methylmercapto-6-methylpyrimidine were obtained in the form of a colorless powder of melting point 156°C.

Provenance & Evidence