Potassium Iodide → HCID 54331295, compound

HRID 1605861Notes

Reaction equation

HRID 1605861 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH:8](Br)[CH2:9][CH2:10][Cl:11])=[O:7])=[CH:4][CH:3]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.[I-].[K+]>C1C=CC=CC=1>[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH:8]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[CH2:9][CH2:10][Cl:11])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 8083MorpholineHCID 30165872-Bromo-4-chloro-1-(4-fluorophenyl)butan-1-one

Product 1

HCID 54331295HCID 54331295, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

15 g. of 1-p-fluorobenzoyl-1-bromo-3-chloropropane, 9.4 g. of morpholine and a catalytic quantity of potassium iodide in 100 cc anhydrous benzene are stirred at room temperature for 36 hrs. The resulting solid is filtered and the filtrate extracted with dilute HCl. The aqueous phase is separated, made alkaline, under cold conditions, with dilute soda solution, and extracted with diethyl ether. The extract is dried and evaporated to give 1-p-fluorobenzoyl-1-morpholino-3-chloropropane.

Workup

  1. filtrationThe resulting solid is filtered
  2. extractionthe filtrate extracted with dilute HCl
  3. customThe aqueous phase is separated
  4. additionunder cold conditions, with dilute soda solution
  5. extractionextracted with diethyl ether
  6. customThe extract is dried
  7. customevaporated

Sources & evidence

ORD record
ord-3f9651a20b36493d8212299207d1ecfc
Source dataset
uspto-grants-1976_04
Patent number
US03951978

Reaction notes

Loading…