5-Amino-4-(thiazol-2-yl)thiophene-3-carbonitrile → N-(4-cyano-3-(thiazol-2-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide
Reaction equation
[NH2:1][c:2]1[c:3](-[c:9]2[s:10][cH:11][cH:12][n:13]2)[c:4]([C:7]#[N:8])[cH:5][s:6]1.[O:14]=[c:15]1[n:16]([CH2:29][C:30](=[O:31])[OH:32])[c:17]2[cH:18][cH:19][c:20]([C:25]([F:26])([F:27])[F:28])[cH:21][c:22]2[cH:23][cH:24]1>>[NH:1]([c:2]1[c:3](-[c:9]2[s:10][cH:11][cH:12][n:13]2)[c:4]([C:7]#[N:8])[cH:5][s:6]1)[C:30]([CH2:29][n:16]1[c:15](=[O:14])[cH:24][cH:23][c:22]2[c:17]1[cH:18][cH:19][c:20]([C:25]([F:26])([F:27])[F:28])[cH:21]2)=[O:31]Participants
3
Sources & evidence
- ORD record
- ord-44dd8c7f69034b7b998106bce72bd80f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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