Methanol → HCID 21545573, compound

Participants

Reaction Steps

A mixture of 1.9 g of 1-[2-oxo-3-(p-fluorophenoxy)propyl]-4-(p-chlorophenyl)-4-hydroxypiperidine, 0.38 g of sodium borohydride and 20 ml of methanol is stirred at room temperature for 3 hours. The resulting mixture is diluted with water and extracted with chloroform. The organic layer is dried over sodium sulfate and evaporated under reduced pressure to give 1-[2-hydroxy-3-(p-fluorophenoxy)propyl]-4-(p-chlorophenyl)-4-hydroxypiperidine, M.P. 103° to 105°C. Recrystallization from benzene-cyclohexane gives white crystals, M.P. 107° to 108°C.

Provenance & Evidence