Ammonia → HCID 21545569, compound

Participants

Reaction Steps

To a solution of 1.85 g of 1-[2-hydroxy-3-(p-fluorophenylthio)propyl]-4-(o-methoxyphenyl)piperazine in 20 ml of glacial acetic acid is added dropwise 1.2 g of 35 % aqueous hydrogen peroxide solution under cooling, and the mixture is stirred at a temperature of 20° to 30°C for 1 hour. The reaction mixture is poured into water, neutralized with aqueous ammonia and extracted with benzene. The organic layer is washed with water, dried over sodium sulfate and evaporated under reduced pressure. The oily residue is crystallized by cooling to give 1-[2-hydroxy-3-(p-fluorophenylsulfinyl)propyl]-4-(o-methoxyphenyl)piperazine, M.P. 164° to 165°C. Recrystallization from benzene gives white crystals, M.P. 167.5° to 168.5°C.

Provenance & Evidence